Diabetes-related erectile dysfunction is caused by a defect in the nitric oxide (NO) mechanism in a part of the brain called the paraventricular nucleus (PVN), a U.S. study finds

The PVN, located in the hypothalamus, plays a role in many functions, including penis erection and sexual behavior. Sexual dysfunction is a common problem in men with diabetes. This study offers new information about the association between diabetes and erectile dysfunction and may help improve treatments, said researchers at the University of Nebraska Medical Center in Omaha. After a series of experiments with Viagra and rats, the researchers concluded that erectile dysfunction in diabetes is due to a defect in the NO mechanisms within the PVN. This defect is the loss in the synthetic enzyme for the production of NO within the neurons of the PVN. Restoring production of this synthetic enzyme may benefit diabetic patients with erectile dysfunction.

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